The 21st century is not in the future: it is happening now. Accelerated changes in technology, migration, demographics, and climate are reshaping the social, economic, and political order. This new configuration creates new demands for the education. How the individuals are trained in this dynamic environment will determine whether these changes become opportunities, which can be effectively capitalized on, to transform positively countries and the region. This report presents some answers and many questions that -although still unresolved- are essential to help people involved in human development to articulate the agenda for the coming years. These aspects are relevant to the side of public policy design and the solution providers in the private sector and civil society organizations.