This research investigates the fulfilment of the right to education of children with disabilities across 21 countries in Eastern and Southern Africa. This study adopted a mixed methods approach combining analysis of data derived from a desk study and that from a small-scale survey. It also incorporated findings and analysis from the country studies conducted in the Comoros, Madagascar and Rwanda where three different research groups, consisting of international researchers and a national researcher, undertook fieldwork, including interviews and school visits. The findings are generally encouraging, though there are mixed levels of political commitment throughout the region. Although the vast majority of Ministries of Education have some degree of responsibility for educating children with disabilities, it is not always clear where central responsibility for this lies. Spreading the responsibility without clarity and accountability could result in a climate in which each ministry is unsure of its role and services are not delivered effectively.