Many educational interventions boost outcomes for girls in settings where girls face education discrimination, but which of those interventions are proven to function effectively at large scale? In contrast to earlier reviews, this Co-Impact evidence review focuses on large-scale programs and policies - those that reach at least 10,000 students - and on final school outcomes such as completion and student learning rather than intermediate school outcomes such as enrollment and attendance. Programs and policies that have boosted access and/or learning at scale across multiple countries include school fee elimination, school meals, making schools more accessible, and improving the quality of pedagogy. Other interventions, such as providing better sanitation facilities or safe spaces for girls, show promising results but either have limited evidence across settings or focus on post-educational outcomes (such as income earning) in their evaluations. We discuss three aspects of considering evidence-based solutions to local problems - constraints to girls’ education, potential solutions, and program costs - as well as lessons for scaling programs effectively. If education systems seek to expand and improve girls’ education at scale, there are tested tools that have performed effectively in multiple settings, even as education leaders, partners, and researchers collaborate to continue innovating and testing new programs at scale.